While Chelsea have struggled in the Premier League, head coach Antonio Conte has guided the Blues to two victories in Europe, including a 2-1 triumph away at Atletico Madrid on matchday two.
The West Londoners can move to the brink of qualification with a win at Stamford Bridge, but Roma will move to the top of Group C with three points on English soil.
Former Roma defender Antonio Rudiger could line up against his former club after signing for Chelsea during the summer.
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