The hosts only need a point tonight to secure their place in the last 16 of the competition with two games to spare, while victory would wrap up top spot in the group.
United, meanwhile, begin the day second in the group but are five points adrift of their opponents after being outclassed by them at Old Trafford a fortnight ago.
Make sure you don't miss a moment of the action courtesy of our minute-by-minute updates below.
OFFICIAL LINE-UPS
JUVENTUS: Szczesny; De Sciglio, Chiellini, Bonucci, Alex Sandro; Khedira, Pjanic, Bentancur; Dybala, Cuadrado, Ronaldo
MANCHESTER UNITED: De Gea; Young, Smalling, Lindelof, Shaw; Herrera, Matic, Pogba; Lingard, Sanchez, Martial
45+1 min JUVENTUS 0-0 MANCHESTER UNITED
45+1 min Ronaldo tries his luck late in the half from range and wins a corner out of it, with his strike taking a def lection and going a few yards wide.
45+1 min There will be a minimum of one minute added time at the end of this first half as Pogba curls a long-range effort towards goal which is gathered by Szczesny.
44 min UPDATE: Real Madrid are well and truly back to form now - they are four goals up before half time away to Plzen, with Bale joining the party.
43 min Dybala swings a free kick into a very dangerous area inside the box and it almost falls to Chiellini, but Herrera gets a crucial toe to it first.
41 min Better from United, but they are lacking a cutting edge in the final third at the moment. They have played with a lot more intensity tonight, but have not tested Szczesny in the Juve goal so far.
39 min United are hanging on a little bit towards the end of this first half. Juve are piling the pressure on right now and the visitors will just want to get to the interval without suffering any damage now.
37 min UPDATE: Real Madrid are now three goals to the good against Plzen through Benzema's second, while elsewhere Benfica and Bayern both lead against Lyon are two up against Hoffenheim.
35 min Juventus are inches away from taking the lead, but they really should be ahead! De Sciglio plays the ball down the right channel for Ronaldo, who in turn puts a low cross into the box. Khedira is unmarked, but he drags his effort against the foot of the post with De Gea beaten.
34 min Really smart stop from De Gea! Cuadrado drilled a low cross into the box from the right flank and it took a deflection off Matic on the way through, forcing De Gea to react quickly in order to keep it out.
33 min United fans may not be happy with the fact that Man City are already two goals to the good, and this is not likely to cheer them up. For the rest of us, though, it is laughable. This is how City were awarded the penalty which led to their second goal!
31 min United win a free kick in a really good position which Sanchez lines up, but his effort goes straight into the wall. Juve immediately break down the other end and Khedira powers a shot towards goal which De Gea needs to save.
29 min United have their brightest attacking moment of the match so far as Matic clips a pass over the defence towards Sanchez, who has timed his run into the box well but just cannot get on the end of the pass.
27 min United are proving a tough nut to crack tonight. Juventus are yet to fashion a really good chance and things are not proving as straightforward as many might have expected on the basis of the reverse fixture.
25 min UPDATE: Ominous signs for United ahead of the derby on Sunday as Man City are already 2-0 up against Shakhtar, with Gabriel Jesus doubling their lead from the spot. Madrid are also 2-0 up against Plzen now as Casemiro makes it a quickfire double for the defending champions.
23 min We're midway through the first half now and, while Juventus are on top right now, Mourinho will be much happier now than he was at the same stage of the reverse fixture. United are putting pressure on the ball and not letting Juventus have things all their own way, which simply wasn't the case at Old Trafford.
21 min UPDATE: A couple of other goals to update you on from elsewhere - Real Madrid lead against Plzen through Karim Benzema, while Nabil Fekir has broken the deadlock for Lyon against Hoffenheim.
19 min...but Pjanic's delivery is uncharacteristically poor and cleared by the first man.
18 min Juventus are slowly gaining a bigger element of control over this game, and they now have a free kick in a good crossing position...
16 min Ronaldo has his first shot of the night as he picks the ball up in space around 30 yards from goal and only ever has one thought in his mind. His shot is dipping, but flies wide with De Gea watching it all the way.
15 min UPDATE: The first goal of the 8pm kickoffs has gone to a Manchester team, but it is City who have taken the lead against Shakhtar through David Silva.
13 min United have started a lot better tonight than they did at Old Trafford, when they gave Juventus far too much room on the ball. However, Juve do look dangerous when they come forward and United will know that they cannot switch off for a second tonight.
12 min Matic picks up an early yellow card for a lunging scissor challenge on Dybala. No complaints there.
10 min Sandro drops the ball back to Bentancur on the edge of the area and the midfielder immediately looks to get a shot away, but his effort is deflected wide of the target.
9 min Pjanic clips a ball forward for Ronaldo, who kills it instantly inside the box but then cannot squeeze his shot past the defender.
8 min Dybala almost needed treatment before this game even began after Szczesny pelted a ball straight at his head!
6 min United have the chance to break after a poor Juventus corner, with Sanchez and Lingard leading the charge. The latter misplaces a simple pass, though, and a really good attacking platform goes begging.
5 min United have started this match brightly, looking to get on the front foot early on, but Juve have just had their first dangerous spell of possession and it took an important block from Lindelof to stop Ronaldo's volley from Dybala's effort.
3 min Poor from Szczesny as he boots the ball straight out of play with the first chance to have the ball at his feet. However, United waste the attacking platform with a foul throw.
1 min Here we go! Manchester United get us underway in Turin!
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