United produced a valiant comeback to register a draw with Southampton at the weekend, but Jose Mourinho's side head into this fixture without a win in three games in the top flight.
Arsenal - on the other hand - are unbeaten in their last 12 matches in the Premier League, and have not suffered defeat in any competition since the second weekend of the season.
The Gunners hold an eight-point advantage over United ahead of Wednesday's showdown at Old Trafford.
OFFICIAL LINE-UPS
MANCHESTER UNITED: De Gea; Bailly, Smalling, Marcos Rojo, Dalot, Herrera, Matic, Darmian; Lingard, Rashford, Martial
MANCHESTER UNITED SUBSTITUTES: Romero, Valencia, Fellaini, Mata, McTominay, Pogba, Lukaku
ARSENAL: Leno; Sokratis, Mustafi, Holding; Bellerin, Torreira, Guendouzi, Kolasinac; Ramsey, Iwobi, Aubameyang
ARSENAL SUBSTITUTES: Cech, Lichtsteiner, Maitland-Niles, Elneny, Mkhitaryan, Nketiah, Lacazette
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